Bioinformatics Seminar


Wednesday, April 15, 2009

3:00 - 4:00

Room 457 Blocker


Martin Dickman


Plant Pathology & Microbiology

Texas A&M University


“Fungal genomics, death and next generation sequencing”





In the past decade, a major revolution in the biological sciences has occurred as a result of the remarkable development and subsequent generation of information/data from genome sequencing efforts. The availability of complete or nearly complete genome sequences is providing the foundation for understanding how organisms (from microbes to humans) function, develop, evolve, interact with pathogens, and respond to environmental cues. A transformational change in the field of biology is stemming from the development of next-generation ultra high-throughput, relatively low-cost DNA sequencing technology. While a rapidly moving target, most next generation sequencing technologies produce read lengths which are much shorter than those obtained from traditional Sanger sequencing technology. The increase in the volume of raw sequences produced combined with the relatively short read lengths of most next generation sequencers is resulting in a number of bioinformatics challenges with regards to sequence processing and downstream analysis to data management/storage issues. Texas A&M University recently acquired the Illumina GAII next generation sequencer which is capable of producing more than 10 billion bases of DNA in just over 8 days. In this talk, I will provide an overview of the Illumina sequencing technology and address some of the challenges we are facing with regards to data analysis and management. In addition, I will discuss the Sclerotinia sclerotiorum genome project, protein modeling efforts  and how all of this interfaces with my laboratory research interests.