Robustness of the Profile Likelihood of a Parameter of Interest Eloisa Diaz-Frances diazfran@cimat.mx Department of Probability and Statistics Centro de Investigacion en Matematicas Guanajuato, 36000, Mexico (This is joint work with David A. Sprott and Jose. Montoya). The profile likelihood function is frequently used to estimate a parameter of interest separately from the remaining nuisance parameters in the model to be considered. It is obtained by replacing the nuisance parameters in the likelihood function by their restricted maximum likelihood estimates corresponding to fixed values of the parameters of interest. Thus this assumes great precision in the estimation of the nuisance parameters. We explore here the changes that the profile likelihood may take under small perturbations in the estimation of the nuisance parameters. In most cases, the profile likelihood results robust under these slight changes. However non robust cases are easily detected and turn out to be indicative of problematic situations that might require careful treatment, and where the profile likelihood might not be informative or reliable. For instance, the Binomial (N,p) model provides an example for both cases, robust and non-robust. The Binomial model is widely used in Ecology to estimate animal abundance. A biological example with non robust profile likelihood of N that was analyzed in Carroll and Lombard (1985) is considered, the number of impala herds in a small area of the Kruger Park in South Africa. A control regular example with robust profile likelihood is also presented for comparison. Carroll, R. J. and Lombard, F. (1985). JASA, V.80, No. 390, pp.423-426.